Tag Archive | "new england journal of medicine"

Study Says Asthma Pills Were as Effective as Inhaled Drugs


British researchers found out that asthma pills were as effective as inhaled steroids in a study that compared the efficacy of both medications.

Dr. Stanley Musgrove, co-author of the study and a senior research associate at the University of East Anglia in Norwich, said that the asthma pills called leukotriene-receptor antagonists should also be considered as treatment option for any patient.

The oral medication has shown similar cost and effectiveness against inhaled steroids, as well as better treatment compliance, Musgrove said. He also said that the study was intended to be a “pragmatic” trial, which means it closely copies the way patients consume medications in real life.

The study consists of 650 volunteers between the age of 12 and 80 with mild to moderate cases of asthma. They had either insufficient control of asthma or had a disrupted quality life because of the condition’s symptoms. The researchers randomly assigned the volunteers to different groups.

The study found out that asthma pills or leukotriene-receptor antagonists work as well as inhaled corticosteroids when utilized as first-line treatment. It also works as well as long-acting rescue medication when utilized as supplementary treatment.

The effectiveness of the medications was measured mainly through Mini Asthma Quality of Life Questionnaire. Findings of the study are published in the New England Journal of Medicine.

St. John Hospital and Medical Center in Detroit chief of allergy and immonology, Dr. Jennifer Appleyard said the findings confirm that there are several options that can be given to asthma patients, and there is not just one answer for them.

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Avastin Effectively Fights Macular Degeneration


Based on the results of a recent study in the United States, Avastin is equally effective against macular degeneration to Lucentis. Avastin is an anti-cancer drug while Lucentis is the leading drug for macular degeneration; Avastis, however, is 40 times cheaper than Lucentis.

The study basically compared Avastin to Lucentis. Both drugs were developed by Genentech, a US firm owned by the Swiss laboratory Roche.

While the test was still ongoing, the researchers randomly assigned a total of 1,208 people with neovascular macular degeneration to get Avastis or Lucentis injections in the eye on a regular basis. That is either done monthly or on an as needed basis, depending on the patients’ monthly evaluation.

Macular degeneration is a condition that usually affects older adults and results in a loss of vision around the center of the visual field due to damage to the retina. It is the most common cause of visual impairment among adults ages 50 and above. This condition will make it almost impossible for the patient to recognize faces, let alone read. However, they usually have enough peripheral vision to allow them to carry on regular daily activities.

After a year of trials, Avastis and Lucentis have the same effects on the respondents’ visual acuity when they are administered following the same schedule. However, the cost of treatment varies widely said Doctor Juan Grunwald, one of the study authors.

The average cost per patient of those who were administered with Lucentis is $23,400. That is a very huge amount of money compared to the $385 cost per patient treated with Avastis.

This study appears in the most recent issue of The New England Journal of Medicine.

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